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Updated: Jul 13, 2025

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
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Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

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了解cGAS-STING通路与脊椎间盘退行性细胞死亡相关的作用的进展

Zheng Wang1,2, Xinli Hu1,2, Peng Cui1,2

  • 1Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Cell death discovery
|October 16, 2023
PubMed
概括

干扰素基因 (STING) 途径的循环GMP-AMP合成酶 (cGAS) 刺激器通过促进炎症驱动椎间盘退化 (IVDD). 针对这种途径为IVDD提供了潜在的治疗策略.

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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

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Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

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The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

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Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Apoptosis01:30

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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