评估因广泛耐药沙门氏菌引起的伤寒疫情的全球风险
Joseph Walker1, Chrispin Chaguza2,3, Nathan D Grubaugh2,3,4
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. jo.walker@yale.edu.
Nature communications
|October 16, 2023
概括
广泛耐药的沙门氏菌 (XDR S. Typhi) 构成了全球威胁. 来自巴基斯坦的航空旅行量是XDR S. Typhi进口和持续传播的关键因素,突出了公共卫生行动的风险国家.
科学领域:
- * 流行病学和公共卫生
- * 传染病的发展动态
- * 基因组流行病学
背景情况:
- *自2016年以来,广泛耐药的沙门氏菌 (Salmonella enterica serovar Typhi,XDR S. Typhi) 已成为巴基斯坦伤寒热的主要原因.
- * XDR S. Typhi的全球传播是一个重大的公共卫生问题,需要确定高风险地区以进行有针对性的干预.
研究的目的:
- * 确定XDR S. Typhi进口和持续传播的高风险国家.
- * 分析国际航空旅行与XDR S. Typhi. 地理传播之间的关系.
- *为减轻XDR型伤寒全球威胁的公共卫生战略提供信息.
主要方法:
- *植物地形建模以评估H58 S. Typhi亚型的移动情况.
- *分析从巴基斯坦到各个国家的年度航空旅行量.
- * 航班行程数据与伤寒发病率估计的整合.
主要成果:
- *来自巴基斯坦的航空旅行量与XDR S. Typhi. 的进口量有显著的相关性.
- * 植物地理模型显示,空中旅行与S. Typhi H58单元型的跨国移动之间存在强烈的关联.
- * 具有高本地传播潜力和与巴基斯坦有很强的旅行联系的国家被确定为风险最高的国家.
结论:
- *国际航空旅行是XDR S. Typhi. 全球传播的关键驱动因素.
- * 确定高风险国家的公共卫生监测和缓解工作的优先考虑至关重要.
- *了解与旅行相关的风险对于控制未来的XDR伤寒疫情至关重要.
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