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下降的GABAergic通路将大脑糖感应与Drosophila中的外周感知门联系起来

Mami Nakamizo-Dojo¹, Kenichi Ishii¹, Jiro Yoshino¹

¹Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Nature communications

|October 16, 2023

概括

饥饿的动物通过抑制疼痛信号来优先考虑食而不是逃跑. 葡萄糖激活特定的大脑神经元,这些神经元抑制疼痛,展示了食逃避行为层次结构.

科学领域:

神经科学是一个神经科学.
动物行为动物行为
分子生物学分子生物学

背景情况:

痛苦的刺激会触发对生存至关重要的防御性逃避行为.
饥饿的动物表现出食优先于逃跑,即使在有害的条件下.
抑制疼痛以促进食的神经机制尚未完全理解.

研究的目的:

确定在饥饿动物养期间抑制 nociception 的分子和细胞机制.
阐明神经回路优先考虑养行为而不是逃跑反应.

主要方法:

在Drosophila幼虫大脑中发现了一种新型GABAergic神经元集群,称为SEZ局部化的下降GABAergic神经元 (SDGs).
研究SDG投射和功能在外围感知神经元和中心目标之间的突触.
分析GABA_B受体在突触前抑制中的作用.
检查葡萄糖传感,胰岛素信号,以及它们对SDG激活和 nociceptive调制的影响.

主要成果:

发现SDG可以投射到外围感知神经元的轴突末端,通过GABA_B受体抑制前突触活性.
向饥饿的幼虫食葡萄糖导致了持续的SDG激活.
这种激活是由葡萄糖感应神经元和随后的胰岛素信号在SDGs中介导的.
SDG激活减弱了 nociception,抑制了对有害刺激的逃避行为.

结论:

确定了一个神经机制,在这个神经机制中,糖在大脑中的感知会使下降的GABAergic神经元 (SDGs) 参与 nociceptive gating.
这种途径表明,在对代谢状态的反应中,养行为是如何在等级上优先考虑的,而不是逃避行为.
这些发现提供了关于整合感官信息以调节竞争生存行为的神经基础的见解.

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