精神分裂症中延迟预测信号引起的异常的代理感:一项计算建模研究
Tsukasa Okimura1,2, Takaki Maeda1,3, Masaru Mimura1,4
1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Schizophrenia (Heidelberg, Germany)
|October 16, 2023
概括
精神分裂症中异常的代理感 (SoA) 可能源于感官运动预测信号的时间延迟. 计算建模证实了这种时间延迟假设,解释了精神分裂症患者的双向SoA缺陷.
科学领域:
- 认知神经科学 认知神经科学
- 计算精神病学是一种计算精神病学.
- 精神分裂症的神经科学 精神分裂症的神经科学
背景情况:
- 异常的代理感 (SoA) 是精神分裂症的核心特征,表现为过度和减少的控制.
- 现有的理论表明,感官运动预测信号的时间延迟 (TDs) 导致了这些SoA异常.
研究的目的:
- 通过计算建模和测试假设,感官运动预测的时间延迟是精神分裂症异常SOA的基础.
主要方法:
- 开发了一个循环神经网络 (RNN) 来模拟感官运动预测过程.
- 在RNN的预测信号中引入了时间延迟,以模仿精神分裂症相关的SOA模式.
- 通过增加噪音或在不同网络组件中引入延迟来进行控制实验.
主要成果:
- 在健康对照中,RNN模型成功地复制了正常的SoA.
- 预测信号中的模拟时间延迟准确地重现了精神分裂症中观察到的双向SoA缺陷.
- 没有预测信号延迟的对照实验没有产生精神分裂症模式的SOA,从而加强了TD假设.
结论:
- 这些发现为精神分裂症中异常SOA的时间延迟假设提供了强有力的支持.
- 这项研究为精神分裂症患者经历的扭曲的代理感提供了一种机械计算解释.
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