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微生物转谷氨酸酶和人类组织抗原之间的交叉反应性和序列相似性

Aaron Lerner^1,2, Carina Benzvi³, Aristo Vojdani⁴

¹Chaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer, Israel. aaronlerner1948@gmail.com.

Scientific reports

|October 16, 2023

概括

微生物转质氨酶 (mTG) 是一种食品添加剂,可能引发自身免疫性疾病. 研究表明mTG与人类抗原有相似之处,这表明它与自身免疫发展有联系.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
食品科学食品科学食品科学

背景情况:

微生物转胺酶 (mTG) 是一种细菌酶,用于食品添加剂.
它的使用可能会产生新的免疫原性表位,可能导致自身免疫.
在自身免疫性疾病的发展中mTG的作用需要研究.

研究的目的:

调查微生物转胺酶 (mTG) 对自身免疫的贡献.
分析mTG与人类自身抗原之间的表位相似性和交叉反应性.

主要方法:

使用Emboss Matcher进行序列对齐,将mTG与自身免疫性疾病相关的抗原进行比较.
用单克隆和多克隆抗体对mTG进行ELISA测试,以测试77种人类组织抗原的反应性.

主要成果:

六种人类抗原与mTG免疫原性表位物显示出显著的序列同样性.
mTG抗体与77个测试抗原中的17个显著反应,特别是线粒体M2,ANA和可提取的核抗原.

结论:

已经证明了mTG和人类组织抗原之间的序列相似性和交叉反应性.
这些发现支持了微生物转胺酶暴露与自身免疫性疾病发展之间的潜在联系.

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