患有骨盆器官脱落的妇女的微生物组变化,以及经过解剖修复干预后的微生物组变化
Myungshin Kim1, Seungok Lee2, Hoon Seok Kim1
1Departments of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
盆腔器官脱落 (POP) 与阴道微生物组的改变有关,乳酸菌含量低,厌氧细菌增加. 像囊或手术这样的治疗方法并没有完全恢复阴道微生物群的健康.
科学领域:
- 妇科健康 妇科健康
- 微生物组研究 微生物组研究
- 阴道微生物组分析
背景情况:
- 骨盆器官脱落 (POP) 是老年女性常见的疾病,导致显著的功能障碍.
- 阴道微生物组在POP和治疗结果中的作用尚未完全理解.
研究的目的:
- 为了研究女性的阴道微生物组合POP.
- 为了分析阴道微生物组的变化后的阴道或手术治疗POP.
- 评估阴道微生物组与炎症标志物之间的相关性.
主要方法:
- 用16S核糖体RNA基因测序来分析阴道微生物组合.
- 多重免疫试验用于测量10种与炎症相关的细胞因子.
- 阴道微生物组概况被比较在POP患者,那些有,和术后患者之间.
主要成果:
- 盆腔器官脱落 (POP) 与第四类阴道社区状况相关,其特点是乳酸菌低,厌氧物种丰富.
- 在POP组中,α多样性最高,而β多样性在三组中显著不同.
- 虽然治疗后人类肠道种群减少,但与阴道炎相关的细菌发生了改变,并且无法实现整体微生物群平衡. 在悲观组中观察到IFN-γ,IL-10,IL-12p70,IL-1β,IL-4和TNF-α的水平增加.
结论:
- 盆腔器官脱落 (POP) 与阴道微生物组的显著变化有关.
- 目前的治疗方法,如囊和手术,可能无法完全恢复阴道微生物组的平衡.
- 针对阴道微生物群恢复的补充策略可能是老年妇女综合性妇科健康管理所必需的.
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