人类休息时脑血管氧化和血液体积中的红外线节奏:一项为期5年的研究
Felix Scholkmann1,2, Hamoon Zohdi3,4, Martin Wolf4
1Institute of Complementary and Integrative Medicine, University of Bern, Bern, Switzerland. Felix.Scholkmann@unibe.ch.
Advances in experimental medicine and biology
|October 16, 2023
概括
人类大脑的氧气和和血量表现出红外线节奏,包括周年和周半年模式. 这些长期的生理变化影响脑血管健康,需要考虑参考值.
科学领域:
- 时间生物学 时间生物学
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
背景情况:
- 人类生理学显示了时代生物学的变异性,昼夜节律已经得到了很好的研究,但红外节律在很大程度上尚未被探索.
- 红外线节奏,周期长度大于24小时,代表了理解人类生理变异性的重大差距.
研究的目的:
- 在健康人群中多年来研究脑血管氧和 (StO2) 和血液体积 ([tHb]) 中的红外线节律性.
- 确定StO2和[tHb]的长期测量是否显示出超出日常周期的模式.
主要方法:
- 频域近红外光谱学 (NIRS) 用于在5年 (2017-2021) 的时间内在220名健康受试者中测量绝对的StO2和[tHb].
- 通过使用通用添加模型 (GAM) 和共模型分析了前额叶和叶708次测量的数据.
主要成果:
- 在5年期间,观察到StO2和[tHb]值的非线性趋势.
- 周年节律 (大约每年) 12个月) 在StO2 (额叶和叶) 和[tHb] (叶) 中被发现.
- 周半年节奏 (大约为每年一个节奏) 6个月) 在[tHb] (额叶) 中被确定,振荡与日长,温度,湿度和气压相关.
结论:
- 绝对的StO2和[tHb]值表明了时代生物学变异性,包括长期非线性趋势和周年/半周年节奏.
- 在确定StO2和[tHb]的参考值时,需要考虑这些红外线节奏.
- 鉴定的节奏可能有助于解释脑血管疾病发病率的年度变化.
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