血管新生素通路的阻塞会影响SARS-CoV-2感染患者的流量体积螺旋测量
Marialuisa Sveva Marozzi1, Francesca Mancini1, Luciana Loponte1
1Unit of Internal Medicine "G. Baccelli" Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, A.O.U.C. Policlinico di Bari, Bari, Italy.
接受血管激素受体抑制剂 (ARB) 或ACE2抑制剂 (ACEi) 治疗的患者在COVID-19后出现呼吸功能降低. 这表明SARS-CoV-2影响肺和血管系统,影响治疗个体的肺功能.
科学领域:
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
- 病毒学 病毒学
背景情况:
- ангиотензин转化酶2 (ACE2) 是一种由SARS-CoV-2利用的细胞受体.
- 肺功能测试 (PFTs),主要是螺旋计,对于诊断和监测呼吸系统疾病至关重要.
- 评估PFT对于评估治疗反应至关重要.
研究的目的:
- 为了评估COVID-19后的患者,使用流量体积螺旋计.
- 研究ACE2通路抑制药物对SARS-CoV-2感染后呼吸功能的影响.
主要方法:
- 在SARS-CoV-2感染3-6个月后评估了112名高加索患者.
- 患者被分为两组:接受 ангиотензин受体阻断剂 (ARB) / ACE2 抑制剂 (ACEi) 的患者和未服用患者.
- 远端空气流阻塞 (DAO) 使用强迫呼气流 (FEF) 在25%,50%和75%的水平进行评估.
主要成果:
- ARB/ACEi组表现出较低的外周氧和 (96.54%与97.30%相比).
- 螺旋测量显示ARB/ACEi组的结果明显更差,包括减少FEV1,FVC和Tiffenau指数.
- 在ARB/ACEi组中存在DAO,减少了FEF 25,FEF 50和FEF 25-75.
结论:
- 接受ARB/ACEi治疗的患者的呼吸功能指数在COVID-19后转向较低,但正常的极限.
- 与未服用这些药物的患者相比,这些参数显著减少.
- 研究结果表明,COVID-19既有肺部影响,也有血管影响.
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