怀孕期间母亲的氧化压力与幼儿时期的情绪和行为问题有关:对胎儿编程的影响
Cindy Pham1,2,3, Sarah Thomson2, Sung-Tong Chin4
1Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Parkville, VIC, 3052, Australia.
Molecular psychiatry
|October 16, 2023
概括
怀孕期间母亲的氧化应激,特别是RNA损伤,与儿童的情绪和行为问题 (EBP) 有关. 早期的环境因素有助于这种压力,部分解释了它们对儿童EBP的影响.
科学领域:
- 围产期流行病学 围产期流行病学
- 环境健康 环境健康
- 发展心理学是发展心理学.
背景情况:
- 儿童情绪和行为问题 (EBP) 越来越令人担忧.
- 怀孕期间母亲的氧化压力 (matOSpreg) 与后代的心理健康问题有关.
- 马托斯普雷格在儿童EBP中的具体作用尚不清楚.
研究的目的:
- 为了研究matOSpreg和后代EBP之间的关联.
- 为了检查社会/产前环境因素和 matOSpreg.之间的关系.
- 确定matOSpreg是否介导环境因素和儿童EBP之间的联系.
主要方法:
- 在怀孕36周时量化了母体尿路氧化应激生物标志物 (8-基瓜诺辛[8-OHGua]和8-基-2'-脱氧瓜诺辛[8-OHdG]).
- 通过问卷收集有关社会和产前环境因素的数据.
- 在2岁和4岁时使用经过验证的尺度 (儿童行为检查表,优点和困难问卷) 评估后代的EBP.
- 采用多变量回归和基于反事实的调解分析.
主要成果:
- 较高的母尿8-OHGua (一种RNA氧化损伤标志物) 与2岁和4岁后代的EBP增加有关.
- 对8-OHdG (一种DNA氧化损伤标志物) 观察到较弱的关联.
- 较低的母亲教育,社会经济劣势和产前吸烟与更高的mat8-OHGua36w和儿童EBP有关.
- 这些环境风险因素通过升高的 matOSpreg. 部分调解了它们对儿童EBP的影响.
结论:
- 在怀孕期间增加的母体氧化应激,特别是RNA损伤,与儿童晚期EBP有关.
- 某些早期社会和环境因素对童年EBP的影响可能部分由母亲的氧化压力解释.
- 需要进一步的研究,才能充分理解早期氧化损伤在儿童EBP中的作用.
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