在PTSD中桃体亚核的功能连接性:一个叙事审查
Elizabeth M Haris1,2, Richard A Bryant3,4, Thomas Williamson4
1School of Psychology, University of New South Wales, Sydney, NSW, Australia. elizabeth.haris@wimr.org.au.
Molecular psychiatry
|October 16, 2023
概括
这次审查检查了在创伤后应激障碍 (PTSD) 中杏仁核亚核连接性. 初步发现表明,PTSD中底侧桃体 (BLA) 连接性发生变化,突出了先进的神经成像技术的必要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 杏仁体在创伤后应激障碍 (PTSD) 中的作用是复杂的,研究结果可能因子核异质性而异.
- 了解杏仁体亚核的功能连接对于阐明PTSD神经生物学至关重要.
研究的目的:
- 综合现有关于PTSD中底侧 (BLA),中枢 (CMA) 和表面 (SFA) 杏仁核的功能连接性的研究.
- 与暴露于创伤和非暴露于创伤的对照人群相比,确定PTSD中改变连接的初步模式.
- 概述局限性,并建议未来研究方向,以研究PTSD中杏仁核子核.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 综合了11项研究,调查了BLA,CMA和SFA在PTSD患者,创伤暴露对照和非创伤暴露对照中的功能连接.
- 分析的重点是跨群体的差异性连接模式.
主要成果:
- 在PTSD (N=331) 中的初步证据显示,与受创伤暴露的对照组 (N=155) 相比,与背部前带状环 ( Salience 检测) 的 BLA 连接性增加.
- 在PTSD中,与非创伤暴露对照组 (N=210) 相比,BLA与中额前 (注意力) 的连接性增加 (N=210).
- 在有限的研究中,没有其他桃体亚核连接被一致复制.
结论:
- 杏仁体亚核的差异连接性对于理解PTSD病理生理学很重要.
- 未来的研究应该考虑创伤类型和性别等调解因素,并利用超高场成像来提高灵敏度.
- 目前的发现受到小样本大小和低场MRI对皮层下结构的限制.
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