介绍固体食物,湿疹和儿童后期喘息的时间:一个纵向队列研究
Curtis J D'Hollander1,2,3, Charles D G Keown-Stoneman3,4, Catherine S Birken5,6,7,8,9
1Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
BMC pediatrics
|October 16, 2023
概括
在4个月,而不是6个月,引入婴儿谷物与在没有家族喘史的儿童中增加湿疹和喘息风险有关. 这些发现支持推迟固体食品的引入,直到大约6个月大.
科学领域:
- 儿科 儿科 儿科
- 过敏学 过敏学
- 流行病学 流行病学
背景情况:
- 在婴儿期引入固体食物的时间与儿童湿疹和喘息有关.
- 之前的研究表明存在联系,但建议中的特定年龄范围需要进一步调查.
研究的目的:
- 调查4至6个月之间的婴儿谷物是否会影响湿疹和喘息的风险.
- 探索家庭喘病史和母乳养时间作为效果修饰物的影响.
主要方法:
- 一项纵向队列研究跟踪了加拿大多伦多的7843名从出生到10岁的儿童.
- 婴儿谷物引入时间是主要暴露;湿疹和喘息 (通过ISAAC问卷) 是主要和次要结局.
- 多项式概括估计方程分析了数据,通过喘病史和母乳养探索了效果的修改.
主要成果:
- 在4个月与6个月的婴儿谷物相比,在没有喘病史且没有母乳养的儿童中,婴儿谷物的引入与疹的几率更高有关 (OR 1.62).
- 在4个月与6个月的婴儿谷物相比,在没有喘史的哺乳期儿童中,婴儿谷物的引入与喘息的几率更高有关 (OR 1.31).
- 家庭喘病史和母乳养时间显著改变了这些关联.
结论:
- 研究结果支持目前推在6个月左右引入固体食物的建议.
- 在特定的儿科群体中,延迟婴儿谷物的引入可能会降低患湿疹和喘息的风险.
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