三甘油糖指数与一般人群中心血管疾病的关联:一个前性队列研究

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Yiming Wan¹, Ziliang Zhang², Yong Ling¹

¹Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Diabetology & metabolic syndrome

|October 16, 2023

概括

甘油三糖 (TyG) 指数与成人心血管疾病 (CVD) 和中风风险增加有关. 这种标记可能有助于早期识别患心血管疾病高风险的个体.

科学领域:

心脏病学心脏病学
代谢综合征是代谢综合征的一种.
公共卫生公共卫生

背景情况:

甘油三糖 (TyG) 指数是胰岛素抵抗的标志物,对一般人群中心血管疾病 (CVD) 风险产生有争议的影响.
本研究探讨了上海一般人口中TyG指数和发生心血管疾病事件之间的关系.

研究的目的:

综合评估TyG指数与发生心血管疾病事件的风险之间的关联.
探索这种关联中潜在的非线性关系和子组差异.

主要方法:

利用了上海郊区成人队列和生物库 (SSACB) 的42,651名参与者的数据.
使用禁食血清甘油三和血糖水平计算的TyG指数.
采用卡普兰-梅尔曲线,日志级别测试和考克斯比例危险模型进行关联分析,包括受限立方线分析.

主要成果:

在平均4.7年的随访期间,1,422名 (3.3%) 参与者患有心血管疾病.
TyG指数增加1个单位与心血管疾病风险增加1.16倍和中风风险增加1.39倍相关.
对心血管疾病和中风观察到线性关系,但并没有观察到冠心病 (CHD). 年轻和患有糖尿病的参与者表现出更高的心血管疾病风险.

结论:

提升的TyG指数与发生心血管疾病和中风的风险增加有关.
泰格指数显示了作为早期指标的潜力,用于识别患心血管疾病高风险的个人.

关键词:

心血管疾病是什么心血管疾病群组研究是指群组研究.三糖-葡萄糖指数是什么意思

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