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Updated: Jul 13, 2025

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
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An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

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维生素C通过H3K9me3脱甲基化激活小鼠胚胎干细胞中的年轻LINE-1元素

Kevin C L Cheng1,2, Jennifer M Frost1, Francisco J Sánchez-Luque3

  • 1Blizard Institute, Faculty of Medicine and Dentistry, QMUL, London, E1 2AT, UK.

Epigenetics & chromatin
|October 16, 2023
PubMed
概括

维生素C (vitC) 通过减少H3K9me3,独立于TET酶,增加多能干细胞中的可转移元素 (TE) 表达. 在小鼠和人类细胞中LINE-1元素的表观遗传调节对细胞功能有潜在的影响.

关键词:
在2-氧格酸盐依赖的二氧化基酶酶.通过DNA甲基化.胚胎干细胞是一种胚胎干细胞.希斯甲基化 希斯甲基化人类 人类 人类 人类 人类线路-1 线路-1 在线鼠标 鼠标是一个鼠标.逆转换是一种逆转换.维生素C 维生素C是一种

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