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在光学连贯性断层扫描中定量血管形态,在初级开放角玻璃眼中进行血管造影

Praneeth Kalva¹, Rubeel Akram¹, Priya Mekala¹

¹Department of Ophthalmology, University of Texas at Southwestern Medical Center, Dallas, TX, USA.

Advances in ophthalmology practice and research

|October 17, 2023

概括

光学连贯断层扫描血管造影 (OCTA) 显示了初级开角玻璃眼 (POAG) 眼睛的血管密度,长度和分支点的减少. 这些OCTA指标,特别是在辐射周毛细血管中,显示了青光眼的诊断潜力.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
血管变化越来越多地被认为是青光眼病因的重要因素.
光学连贯断层扫描血管造影 (OCTA) 提供眼球血管系统的高分辨率可视化.

研究的目的:

使用OCTA量化比较健康眼睛和POAG眼睛之间的血管形态.
为了评估特定的OCTA衍生的血管参数在区分青光眼的诊断价值.

主要方法:

这是一项涉及49名健康受试者和49名POAG患者的回顾性,横截面研究.
分析了斑点和视神经头部 (ONH) 的OCTA扫描.
测量和比较了船舶密度 (VD),船舶长度密度 (VLD) 和分支点密度 (BPD).

主要成果:

与健康的眼睛相比,患有POAG的眼睛显著减少了VD,VLD和BPD (P < 0.001).
辐射周周毛细管 (RPC) VD 显示了最高的诊断性能 (AUC:0.939).
在RPC层中的VLD和BPD显示了与VD相比的诊断价值.

结论:

降低的血管形态参数 (VD,VLD,BPD) 是POAG的特征.
来自OCTA的血管指标,特别是在RPC层中,对青光眼的诊断和评估充满希望.
血管形态参数可以提供超越传统方法的补充诊断信息.

关键词:

眼光障碍眼光障碍眼光障碍眼光障碍光学连贯性断层扫描血管图谱.船舶密度船舶密度船舶密度

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