在由主要不同的登革热血型引起的流行病期间,血清阳性登革热患者的眼睛表现
Ajeet M Wagle1,2,3,4, Smita R Hegde4,5, Srinivasan Sanjay4,6
1International Eye Cataract Retina Centre, Mount Elizabeth Medical Centre, Singapore.
Advances in ophthalmology practice and research
|October 17, 2023
概括
登革热病毒血清型1 (DENV-1) 疫情比DENV-2疫情显示出更多的眼科问题,如视力障碍和棉花斑. 在DENV-1爆发期间,肝功能也受到更大的影响.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 登革热 (DF) 是一个重要的公共卫生问题,流行病是由不同的登革热病毒血清型 (DENV) 驱动的.
- 眼科症状是已知的登革热感染并发症,但它们的患病率可能因循环中的DENV血清型而异.
研究的目的:
- 在新加坡连续两次登革热流行期间调查和比较眼科症状的流行率.
- 确定主要由DENV-1和DENV-2引起的流行病之间的眼科和实验室特征的差异.
主要方法:
- 纳入了2005年6月至2007年12月期间入院的血清阳性登革热患者队列.
- 收集和分析了人口,眼科和实验室数据,以比较DENV-1和DENV-2流行流行病之间的特征.
- 进行眼科检查和实验室测试以评估结果.
主要成果:
- 在完成研究的109名患者中,33人来自2005-2006年 (DENV-1占主导地位) 流行病,76人来自2007年 (DENV-2占主导地位) 流行病.
- 在DENV-1流行期间观察到较高的色视障碍 (36.4%vs18.7%),棉花斑 (30.3%vs3.9%) 和出血透析 (21.2%vs3.9%) 的比率.
- 异常的肝功能测试,包括ALT和AST升高,在DENV-1流行病患者中也明显更频繁.
结论:
- 与DENV-2流行病相比,登革热病毒血清型1 (DENV-1) 流行病与特定眼科症状的更高流行率有关.
- 在DENV-1爆发期间,眼科并发症,如色彩视力障碍,棉花斑和出血性透析,以及肝功能异常,更常见.
相关概念视频
Glaucoma: Overview
599
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
599
Endocarditis II: Clinical Features of Infective Endocarditis
11
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
11
Accessory Structures of the Eye
1.6K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.6K
Open Angle Glaucoma: Treatment
459
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
459
Angle Closure Glaucoma: Treatment
536
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
536
Photoreceptors and Visual Pathways
6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K


