吸烟改变了暴露和发生缺血性中风之间的关联:REGARDS研究
Yijia Zhang1,2, Qi Yan1, Meghan Angley1,2
1Department of Obstetrics and Gynecology (Y.Z., Q.Y., M.A., L.L., R.W.F., K.K.), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York.
Stroke
|October 17, 2023
概括
住宅中的暴露与缺血性中风风险有关,特别是在从未吸烟的人群中. 这项研究强调了影响中风发病率的潜在环境因素,强调了对室内水平的进一步研究的必要性.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 心血管疾病研究研究
背景情况:
- 暴露是肺癌的已知危险因素之一.
- 关于住宅与中风风险的联系的研究是有限的.
- 了解中风病因中的环境因素至关重要.
研究的目的:
- 调查住宅暴露和发生的缺血性中风之间的关联.
- 探索这种关联是否根据吸烟状况而有所不同.
主要方法:
- 利用了来自45岁以上成年人REGARDS队列 (n=26,950) 的数据.
- 将县级子测量与参与者的居住历史联系起来.
- 采用Cox比例危险回归模型来分析到缺血性中风的时间.
主要成果:
- 在调整了混杂因素后,暴露与从未吸烟者发生的缺血性中风有显著的相关性 (HR,1.39;95% CI,1.01-1.90).
- 在常吸烟者中,暴露和缺血性中风之间没有发现显著的关联.
- 使用替代测量的灵敏度分析支持了主要发现.
结论:
- 住宅中的暴露可能会增加缺血性中风风险,特别是在从不吸烟者中.
- 吸烟状态似乎改变了和中风之间的关系.
- 需要通过室内直接测量气的进一步研究来证实这些发现.
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