对于严重的Stenotrophomonas maltophilia感染的治疗方法
Maria F Mojica1,2,3, Robert A Bonomo2,4,5, David van Duin6
1Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University.
Current opinion in infectious diseases
|October 17, 2023
概括
治疗Stenotrophomonas maltophilia感染是具有挑战性的,因为多种药物耐药性. 目前的第一线疗法,如三甲-硫甲醇 (SXT),缺乏强烈的PK/PD相关性,导致组合疗法或新药的推.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 斯坦诺托福蒙纳斯 (Stenotrophomonas maltophilia) 是一种具有内在多药性耐药性的机会性病原体,这给临床治疗带来了重大挑战.
- 由于抗药性模式的增加,S. maltophilia感染的有效治疗策略至关重要.
结论:
- 优化S. maltophilia治疗需要更多的PK/PD数据和受控的临床研究.
- 目前对严重感染的建议包括SXT,LVX,MIN或FDC的联合治疗,或CZA-ATM的单一治疗.
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