关于SARS-CoV-2与肝脏之间的联系的当前观点:朋友还是敌人?
Roberto Lovero1, Ioannis Alexandros Charitos2, Skender Topi2
1Clinical Pathology Unit, AOU Policlinico Consorziale di Bari - Ospedale Giovanni XXIII, Bari 70124, Italy.
Endocrine, metabolic & immune disorders drug targets
|October 17, 2023
概括
胃肠道症状,包括恶心和腹,在感染SARS-CoV-2的患者中很常见. 这些症状可能表明预后较差,并且与肠道微生物群失调和肠/肝轴改变有关.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行已经产生了广泛的负面影响.
- 由于患者激增,医院系统面临前所未有的压力.
- 在SARS-CoV-2患者中经常观察到胃肠道 (GI) 症状.
研究的目的:
- 突出SARS-CoV-2感染中胃肠道症状的流行程度和重要性.
- 为了研究胃肠道症状,肝功能和疾病严重程度之间的关联.
- 探索肠道微生物群失调和肠/肝轴在SARS-CoV-2感染中的作用.
主要方法:
- 审查SARS-CoV-2患者的临床数据和症状.
- 生物化学肝功能测试的分析.
- 在便和呼吸道样本中检测SARS-CoV-2RNA.
主要成果:
- 大约10%的SARS-CoV-2患者出现了孤立的胃肠道症状 (恶心,吐,腹,厌食症).
- 生物化学性肝脏疾病很常见,与预后较差和ICU入院增加相关.
- SARS-CoV-2 RNA 在便样本中可检测,即使在呼吸检测结果为阴性后,直肠拭子也显示出与鼻腔拭子相似的灵敏度.
结论:
- 胃肠道症状是SARS-CoV-2感染的重要特征,应在初步诊断时考虑.
- 胃肠道症状和肝功能障碍的存在与更糟糕的临床结果有关.
- 感染SARS-CoV-2可能导致肠道微生物群失调,影响肠/肝轴.
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