[关于多发性骨髓瘤中博尔特佐米布抗性的机制的研究进展]
1Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Zhongguo shi yan xue ye xue za zhi
|October 17, 2023
概括
多发性髓瘤 (MM) 是一种常见的血液癌症. 本综述探讨了癌细胞如何抵抗博特佐米布 (BTZ) 治疗,并讨论了克服耐药性的新疗法策略.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 多发性骨髓瘤 (MM) 是第二常见的血液性恶性瘤,是血细胞的癌症.
- 近20年来,蛋白酶体抑制剂,如博尔特佐米布 (Bortezomib,BTZ) 已成为MM治疗的基石.
- 尽管在治疗方面取得了进展,但MM仍然在很大程度上无法治愈,原因是药物耐药性的发展.
结论:
- 对MM药物耐药机制的进一步研究是必不可少的.
- 针对抗药性途径的新型治疗方法有望改善MM患者的预后.
- 克服博特佐米布耐药性可以显著提升MM治疗.
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