相关实验视频

Updated: Jul 13, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

抗LAG-3在癌症治疗中的进展

Yunong Li¹, Mingyi Ju¹, Yuxi Miao¹

¹Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, P.R. China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|October 17, 2023

概括

针对淋巴细胞激活基因-3 (LAG-3) 的新型免疫检查点抑制剂在增强癌症免疫疗法方面表现有前途. 抗LAG-3药物与其他治疗相结合,可以放大治疗反应,并产生可控的副作用.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,但面临着药物耐药性和免疫相关副作用等挑战.
淋巴细胞激活基因-3 (LAG-3) 是一个关键的共抑制受体,调节免疫反应.
最近FDA对LAG-3抑制剂在联合治疗中获得批准,对LAG-3的治疗潜力重新产生了兴趣.

研究的目的:

审查LAG-3的细胞间和细胞内机制.
为了澄清LAG-3在瘤微环境中的作用.
确定当前的LAG-3治疗剂和临床试验,并讨论未来的前景.

主要方法:

关于细胞间和细胞内LAG-3机制的文献综述.
分析LAG-3在瘤微环境中的作用.
识别和讨论当前的LAG-3相关治疗剂和临床试验.

主要成果:

LAG-3 作为免疫反应的负调节剂.
抗LAG-3药物可以增强其他ICI的疗效.
涉及LAG-3抑制剂的组合疗法表现出可控的副作用.

结论:

LAG-3是新型癌症免疫疗法的一个有前途的目标.
LAG-3 抑制剂有可能改善各种癌症的治疗结果.
进一步研究基于LAG-3的疗法是有必要的,以克服目前的局限性.

关键词:

现场行动组-3 免疫检查点抑制剂免疫检查点抑制剂淋巴细胞激活基因-3 基因-3 黑色素瘤是一种黑色素瘤.有关可能的关系.

更多相关视频

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients

Published on: September 25, 2018

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.