在患有先天性心脏病的胎儿中,总和区域大脑容量
Daniel Cromb1, Alena Uus1,2, Milou P M Van Poppel2,3,4
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Journal of magnetic resonance imaging : JMRI
|October 17, 2023
概括
胎儿的先天性心脏病 (CHD) 与大脑基质输送减少时的大脑体积较小有关. 然而,如果基质的输送保持正常,大脑发育不受影响.
科学领域:
- 神经成像是一种神经成像.
- 发展生物学 发展生物学
- 心脏病学 心脏病学
背景情况:
- 先天性心脏病 (CHD) 是一种影响胎儿发育的常见疾病.
- 心血管疾病与大脑发育受损和神经发育结果有关.
- 将心血管疾病与大脑发育问题联系在一起的确切机制尚不清楚.
研究的目的:
- 调查预期的大脑基质分娩与患有心脏病的胎儿的胎儿大脑体积之间的关联.
- 使用MRI数据,比较患有心脏病的胎儿和典型发育的胎儿的大脑容量.
主要方法:
- 一项追溯病例对照研究,涉及380名胎儿 (45名对照,335名心血管疾病患者) 在妊娠29-37周之间进行扫描.
- 磁力共振成像数据 (T2加权和平衡的稳定状态自由前行序列) 用1.5T扫描仪获取.
- 使用自动图像处理,包括使用卷积神经网络进行运动校正,重建和细分.
主要成果:
- 患有心血管疾病和脑基质减少的胎儿的总和区域大脑体积较小.
- 在对照胎儿和患有心脏病但基质分娩正常的胎儿之间,没有发现大脑体积的显著差异.
- 严重减少的大脑基质输送与较低的大脑与身体体积比率相关.
结论:
- 在患有心血管疾病的胎儿中,大脑基质分娩减少与大脑总和区域体积的减少有关.
- 胎儿大脑体积在CHD病例中没有显著影响,预计正常的脑基质分娩.
- 这些发现强调了基质输送在胎儿大脑生长中的关键作用,在心脏病的背景下.
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