一项前性研究,分析LC-MS/MS消毒后手伤中的八胺度
Susanne Langen1, Patrick Lötscher1, Jean-Christophe Prost2
1Department of Plastic and Hand Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
International wound journal
|October 17, 2023
概括
含有octenidine (OCT) 的消毒剂可以在开放的伤口中引起有毒反应. 这项研究在使用Octenisept®后的组织样本中检测到OCT,这表明在诊断污染或有毒作用时要谨慎.
科学领域:
- 毒理学 毒理学 毒理学
- 伤口护理 伤口护理
- 分析化学 分析化学
背景情况:
- 使用八胺 (OCT) 消毒剂的压力冲洗可以引起有毒反应.
- 在外科消毒中使用OCT可能会使污染诊断复杂化.
研究的目的:
- 在开放手部撕裂的消毒前和之后,量化海上国家和地区在皮下组织中的度.
- 评估Octenisept®对伤口组织中OCT水平的影响.
主要方法:
- 从患有开放手部伤的患者收集了皮下组织样本.
- 使用LC-MS/MS对Octenisept®消毒前和后的样本进行了分析.
- 采用超高性能液态色谱与并联质谱 (LC-MS/MS) 的技术.
主要成果:
- 在20个组织样本中,在消毒后16个样本中检测到octenidine (OCT).
- 海外国家和地区的平均度从消毒前的0.6 pg/mL/mg显著增加到消毒后的179.4 pg/mL/mg.
- 检测到的OCT水平是可量化的,其下限量化值 (LLOQ) 为10 pg/mL/mg.
结论:
- 通过Octenisept®消毒,可以在开放的伤口中获得可量化的OCT度.
- 如果怀疑OCT介导的有毒反应,请避免含有OCT的消毒剂.
- 这一发现对于在怀疑有毒反应的情况下进行准确诊断至关重要.
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