周围血液细胞计数比率作为急性缺血性中风患者功能表现不佳的预测指标
Mihael Emilov Tsalta-Mladenov1,2, Silva Peteva Andonova1,2
1Department of Neurology and Neuroscience, Faculty of Medicine, Medical University "Prof. Paraskev Stoyanov", Varna, Bulgaria.
Neurological research
|October 17, 2023
概括
较高的中性粒细胞-淋巴细胞比率 (NLR) 和血小板-淋巴细胞比率 (PLR) 预测急性缺血性中风 (AIS) 患者的结果不佳. 这些简单的血液检查可以帮助评估中风后的长期预后.
科学领域:
- 神经学 神经学
- 炎症生物学 炎症生物学
- 生物标志物研究 生物标志物研究
背景情况:
- 急性缺血性中风 (AIS) 是导致死亡和残疾的主要原因.
- 血栓炎症是AIS病理生理学的关键因素.
- 像NLR,PLR和LMR这样的外周血细胞计数比率 (PBCCRs) 是AIS中具有预后潜力的炎症指标.
研究的目的:
- 调查NLR,PLR,LMR和AIS后三个月的功能结果之间的关联.
- 评估这些PBCCRs在AIS患者的预后价值.
主要方法:
- 对141名AIS患者进行了前性研究.
- 在中风发作后24小时内测量PBCCRs.
- 在出院后和3个月后,使用修改的兰金度量表 (mRS) 评估功能结果,并通过NIHSS测量中风严重程度.
主要成果:
- 3个月后结果不佳的患者 (mRS>3) 淋巴细胞数量较低,NLR,PLR和C反应蛋白更高.
- 较高的NLR和PLR与更糟糕的结果相关.
- 对ROC曲线的分析表明,NLR (AUC=0.626) 和PLR (AUC=0.613) 对于不良结果的可预测性.
结论:
- 中性细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 是AIS的有价值的预后生物标志物.
- 这些比率很容易获得,具有成本效益,并有助于预测中风后三个月的临床结果.
关键词:
血细胞计数是指血液中的细胞数量.血细胞计数比率是血细胞计数比率.缺血性中风是因为缺血性中风.一次性中风,中风.临床结果 临床结果淋巴细胞与单细胞的比率.中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比率.预后 预后 预后更多相关视频
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
3.4K
06:37Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
Published on: July 14, 2023
919
相关概念视频
Structure and Function of Leukocytes
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
