与COVID-19相关的粘膜菌的激增:对多途径机制的审查
Mohsen Pourazizi1, Atousa Hakamifard2, Alireza Peyman1
1Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Parasite immunology
|October 17, 2023
概括
粘菌菌,一种严重的真菌感染,在COVID-19期间激增. 在COVID-19患者的关键危险因素包括高血糖症,免疫缺陷和医疗治疗,需要警检测以有效管理.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 粘菌菌是一种严重的真菌感染,由Mucorales菌引起.
- 在COVID-19大流行期间,全球范围内观察到粘膜菌病例的显著增加,称为COVID-19相关的粘膜菌病 (CAM).
- 由于CAM呈现严重的发病率和死亡率,使COVID-19治疗复杂化.
研究的目的:
- 在有COVID-19感染史的个体中识别和分类粘膜菌的主要风险因素.
- 增强对CAM多因素性质的理解.
- 为临床警和早期检测策略提供信息.
主要方法:
- 在COVID-19患者中审查和分类与粘膜菌相关的潜在风险因素.
- 确定了10个主要的风险因素类别.
- 对环境因素,宿主相关因素和阳性因素的分析.
主要成果:
- 在COVID-19幸存者中确定了十个关键的风险因素类别,用于粘膜菌.
- 这些包括急性高血糖症,细胞因子释放,免疫缺陷,内皮功能障碍,铁失调,代谢酸性,器官损伤,并发症 (如糖尿病),环境暴露和阳性因子 (如葡萄糖皮质激素使用).
- 这些因素有助于潜在的危及生命的感染.
结论:
- 与COVID-19及其治疗相关的几个因素可能会增加粘膜菌的风险.
- 医生必须保持高度警,在有COVID-19病史的患者中检测粘膜菌.
- 早期检测和管理对于改善CAM患者的治疗结果至关重要.
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