在患有潮湿与年龄相关的黄斑退化症的患者中补充AREDS2
Nidal Siag1, Ran Moshkovsky2, Nili Golan3
1Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association journal : IMAJ
|October 17, 2023
概括
饮食补充剂,根据年龄相关眼病研究2 (AREDS2) 的建议,可能会减少湿性与年龄相关的黄斑变性 (AMD) 的抗血管内皮生长因子注射. 然而,这项研究没有发现治疗结果的统计学上显著差异.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 营养科学 营养科学
背景情况:
- 抗血管内皮生长因子 (anti-VEGF) 疗法显著推进了湿性与年龄相关的黄斑变性 (AMD) 治疗.
- 众所周知,这些治疗方法可以稳定和改善湿 AMD 患者的视力.
研究的目的:
- 调查与年龄相关的眼病研究2 (AREDS2) 推的食补充剂对湿 AMD 患者抗 VEGF 注射的频率的影响.
- 评估AREDS2补充剂是否会影响三年内所需的抗VEGF治疗次数.
主要方法:
- 一项回顾性研究涉及57名湿性AMD患者接受抗VEGF注射.
- 研究组 (27名患者) 在治疗前至少一年接受AREDS2补充剂,而对照组 (30名患者) 没有.
- 主要结局:在3年内注射抗VEGF的次数. 二次结果:视力敏度和中央黄斑厚度.
主要成果:
- 服用AREDS2补充剂的患者在3年内平均需要21.89次注射,而对照组 (P=0.083) 需要26.00次注射.
- 两组之间在最终视力敏度 (P=0.09) 或中央黄斑厚度 (P=0.38) 上没有观察到统计学上显著的差异.
- 虽然研究小组倾向于减少注射量,但差异没有达到统计学意义.
结论:
- 在三年内,AREDS2的食补充剂并没有导致对湿性AMD的抗VEGF注射的统计学显著减少.
- 该研究发现,在补充和对照组之间,视觉敏度或中央黄斑厚度没有显著差异.
- 可能需要进一步的研究来探索营养补充剂的长期影响和最佳使用,以管理湿 AMD.
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