眼睛中的微流体:从工程角度来看,对青光眼的植入物进行了审查
Zecong Fang1, Shuzhen Bi2, J David Brown3
1Bionic Sensing and Intelligence Center (BSIC), Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China. tingrui@ustc.edu.cn.
Lab on a chip
|October 17, 2023
概括
用微流体检查玻璃眼植入物,以改善水性湿液排水和降低眼内压力 (IOP). 未来的微系统有望通过人工智能控制,无线的IOP管理来更好地治疗青光眼.
科学领域:
- 眼科和生物医学工程眼科和生物医学工程
- 医疗器械中的微流体.
- 眼的治疗策略和治疗策略
背景情况:
- 青光眼是导致不可逆转的失明的主要原因,全球有超过7000万人受到影响.
- 升高的眼内压力 (IOP) 是阻止青光眼进展的首要目标.
- 目前的治疗方法包括微流体装置,如青光眼排水装置 (GDD) 和微创性青光眼手术 (MIGS),以管理水性幽默 (AH) 流出.
研究的目的:
- 分析自然和人造的微流体通道,以检测青光眼中的AH.
- 为了提供对IOP异常的洞察力,并改进当前的玻璃眼植入物设计.
- 从微流体学的角度批判性地审查绿眼的植入物.
主要方法:
- 详细建模和分析AH微流体通道 (自然和人工).
- 根据AH排水目标,对当前的玻璃眼植入物进行分类,分为四组.
- 对植入机制的审查和分类到三个技术波段:微管,微和微系统.
主要成果:
- 目前的植入物按排水位分类:施莱姆运河,上空间,副结膜空间和眼睛表面.
- 玻璃眼植入物设计被分为三个进化波:微管,微和微系统.
- 微流体原理为理解和改善青光眼植入物疗效提供了一个框架.
结论:
- 未来的玻璃眼治疗微系统将整合人工智能,用于积极的无线IOP控制和实时监控.
- 改进的微流体设计可以提高安全性,减少并发症,并提高IOP降低效率.
- 对微流体结构和功能的进一步研究对于推进青光眼植入物技术至关重要.
相关概念视频
01:25Glaucoma: Overview
599
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
599
01:27Open Angle Glaucoma: Treatment
459
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
459