SGLT2 抑制剂和糖尿病视网膜病变的进展
Jennifer B Nadelmann1, Charles G Miller1, Brendan McGeehan2
1Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, 51 North 39Th St, Philadelphia, PA, 19104, USA.
概括
-葡萄糖共载体2 (SGLT2) 抑制剂没有恶化非增殖性糖尿病视网膜病变 (NPDR) 的进展. 这项研究发现,在使用SGLT2抑制剂的患者中,视力威胁的糖尿病视网膜病变,增殖性糖尿病视网膜病变或糖尿病黄斑胀的风险没有增加.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- -葡萄糖共运输体2 (SGLT2) 抑制剂越来越多地用于2型糖尿病管理.
- SGLT2 抑制剂对 DR 进展的影响需要进一步研究.
研究的目的:
- 确定SGLT2抑制剂是否影响非增殖性糖尿病视网膜病变 (NPDR) 的进展.
- 为了比较SGLT2抑制剂使用者和非使用者之间危及视力的糖尿病视网膜病变 (VTDR),增殖性糖尿病视网膜病变 (PDR) 和糖尿病黄斑胀 (DME) 的风险.
主要方法:
- 使用医疗索赔数据 (2013-2020) 的回顾性队列研究.
- 纳入患有NPDR的患者,不包括以前有VTDR,PDR,DME或VTDR治疗的患者.
- 逆概率治疗权重 (IPTW) 和考克斯比例危险回归来评估结果.
主要成果:
- 6065名SGLT2抑制剂使用者与12890名对照者进行了匹配.
- 在IPTW后的SGLT2抑制剂组和对照组之间,VTDR,PDR或DME发生率没有显著差异.
- 对VTDR,DME和PDR的危险比分分别为1.04,1.03和1.22.
结论:
- 用SGLT2抑制剂治疗与NPDR进展的风险增加无关.
- 这些发现表明,SGLT2抑制剂可以安全地用于NPDR患者.
- 进一步的研究可能会探索长期影响和特定的患者子组.
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