在患有抑郁症和1型糖尿病的患者中,微生物组组成和中枢血清活性
Vera Flasbeck1, Julia Hirsch2, Frank Petrak2
1Department of Psychiatry, LWL-University Hospital, Ruhr University Bochum, Bochum, Germany.
European archives of psychiatry and clinical neuroscience
|October 17, 2023
概括
肠道微生物群的组成影响了中枢的血清素活性. 改变肠道细菌的多样性与1型糖尿病和抑郁症患者的大脑血清功能的降低相关.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究的研究.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肠-大脑轴在主要抑郁症病理生理学中至关重要.
- 改变的肠道微生物群会影响托的新陈代谢和中枢神经系统 (CNS) 的血性神经传递.
- 之前的研究经常单独检查微生物群或中枢神经系统血清素.
研究的目的:
- 调查肠道微生物群组成和中枢血清激素活性之间的联系.
- 利用听觉唤起潜力的强度依赖 (LDAEP) 作为中枢神经系统血清素活性的神经生理学标记.
- 分析1型糖尿病和抑郁症患者的这些关系.
主要方法:
- 招募了三个组:1型糖尿病和抑郁症患者 (D+D),1型糖尿病患者 (D-) 和健康对照 (HC).
- 分析了便微生物群组成 (α和β多样性).
- 使用LDAEP测量了使用LDAEP的中央血清激素活性.
主要成果:
- 在D+D患者中,高肠道微生物群α-多样性与高LDAEP (表明中枢血清活性较低) 相相关.
- 丰富的细菌群,蛋白质细菌和坚果菌影响了中央的血清活性.
- 一个趋势表明,在两个糖尿病组中,中央血清激素活性和细菌菌体-菌体比率之间存在关联.
结论:
- 肠道微生物群的组成可以显著调节中央血清活性.
- 这突出了一个潜在的机制,将肠道健康,大脑功能和糖尿病抑郁症联系在一起.
- 在精神病和代谢条件下对肠-大脑轴的进一步研究是有必要的.
相关概念视频
Antidepressant Drugs: MAOIs and Other Agents
254
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
254
Depression: Overview
256
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
256
Psychoneuroimmunology: Diabetes and Cancer
31
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
31
Depressive Disorders: MDD and Dysthymia
138
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
138
Depressive Disorders: Etiology
104
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
104
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
410
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
410


