饮食对乳腺癌复发的影响:DIANA-5随机试验
Franco Berrino1,2, Anna Villarini3, Giuliana Gargano1
1Department of Epidemiology and Data Science, S.C. Epidemiology and Prevention, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
概括
在DIANA-5试验中,没有发现巨型地中海饮食对乳腺癌复发的显著降低. 然而,更严格地遵守饮食建议显示出潜在的保护作用,防止复发.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 预防医学 预防医学
背景情况:
- 乳腺癌复发仍然是高风险患者的一个重大问题.
- 饮食干预措施被探索为一种减轻复发风险的策略.
- 宏观地中海饮食结合了传统地中海和宏观生物饮食模式的元素.
研究的目的:
- 评估宏观地中海饮食在降低高风险个体乳腺癌复发的有效性.
- 评估遵守特定饮食建议对复发率的影响.
主要方法:
- 在DIANA-5随机对照试验中,招募了1542名高风险乳腺癌患者.
- 参与者被分配到接受大地中海饮食的干预组 (IG) 或控制组 (CG).
- 使用饮食指数来衡量饮食遵守,在5年的随访期间比较推和不推的食物.
主要成果:
- 在IG和CG之间没有观察到乳腺癌复发的统计学上显著差异 (HR = 0.99;95%CI:0.69-1.40).
- 对组合组的分析表明,坚持饮食的女性 (饮食指数变化的上三位数) 的复发风险较低 (HR = 0.59;95% CI:0.36-0.92).
结论:
- DIANA-5饮食干预没有显示乳腺癌复发的显著减少.
- 较高的遵守宏观地中海饮食建议与预防复发的保护作用有关.
- 进一步的研究可能是有必要的,以探索饮食遵守的细微差别及其对癌症结果的影响.
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