和维生素E用于预防非肌肉侵入性膀癌复发和进展:一项随机临床试验
Richard T Bryan1, Sarah J Pirrie2, Ben Abbotts1
1Bladder Cancer Research Centre, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
JAMA network open
|October 17, 2023
概括
补充剂没有防止非肌肉侵入性膀癌复发. 然而,补充维生素E增加了这些患者的复发风险. 需要进一步的研究来了解维生素E.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 临床试验 临床试验
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 的复发和进展带来了重大的临床挑战.
- 和维生素E已被研究出它们在NMIBC中的潜在化学预防作用.
研究的目的:
- 评估和/或维生素E在新诊断为NMIBC的患者中预防疾病复发的疗效.
- 评估和维生素E对疾病进展和整体存活时间的影响.
主要方法:
- 一个多中心,前性,双盲,安慰剂控制,2x2因子随机临床试验.
- 270名新诊断的NMIBC患者被随机分配,接受口服,维生素E,两者,或安慰剂.
- 随访的重点是无复发间隔 (RFI),无进展间隔和整体存活率.
主要成果:
- 补充剂对RFI没有显著影响 (HR,0.92;P=.65).
- 维生素E补充与复发风险的统计显著增加有关 (HR,1.46;P=.04).
- 两种补充剂都没有影响无进展间隔或整体存活率.
结论:
- 在减少NMIBC复发方面没有效果.
- 补充维生素E可能是有害的,增加了NMIBC患者的复发风险.
- 需要对维生素E作用背后的生物机制进行进一步的研究.
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