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Updated: Jul 13, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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合成大麻素受体激动剂的微妙结构修改大大提高了其在CB1受体的有效性

Hideaki Yano1, Rezvan Chitsazi2, Christopher Lucaj1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States.

ACS chemical neuroscience
|October 17, 2023
PubMed
概括

合成大麻素受体激活剂 (SCRA) 的轻微结构变化可以显著改变它们在CB1Rs的效力和有效性. 这凸显了毒性潜力和监测新型SCRAs的必要性.

关键词:
生物发光共振传输能量转移.大麻素受体 1 1 大麻素受体分子动力学分子动力学合成大麻素是一种合成大麻素.

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