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通过皮肤诱导布普伦诺芬48小时到延长释放布普伦诺芬
Pouya Azar1, James S H Wong, Nickie Mathew
1From the Integrated Psychiatry, Pain, and Addiction Service, Vancouver General Hospital, Vancouver, British Columbia, Canada (PA, JSHW, NM, MJI); Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada (PA, NM); Addictions and Concurrent Disorders Research Group, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada (JSHW, RMK); BC Mental Health & Substance Use Services, Provincial Health Services Authority, British Columbia, Canada (NM); Substance Use Response and Facilitation Service, BC Children's Hospital, Provincial Health Services Authority, British Columbia, Canada (MJI); Pharmaceutical Sciences, Vancouver General Hospital, Vancouver, British Columbia, Canada (NP); Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (NP); British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada (AA, MH, RB, JSGM); Pharmacokinetics Modeling and Simulation Laboratory, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada (ST, ARM); Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (MH); School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (RB); and Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (JSGM).
布普伦诺芬延长释放剂 (BUP-XR) 为阿片类药物使用障碍提供持续的症状控制. 一种新的48小时透皮诱导成功启动了BUP-XR,最大限度地减少了住院患者的戒断.
科学领域:
- 成 药物 药物 药物 药物
- 药理学 药理学是指药理学的学科.
- 临床治疗学 临床治疗学
背景情况:
- 阿片类药物使用障碍 (OUD) 是一种慢性复发性疾病,需要有效的长期管理.
- 布普伦诺啡延长释放剂 (BUP-XR) 是一种有效的每月注射治疗OUD,改善了患者的治疗结果.
- 标准的BUP-XR诱导方案建议至少7天的跨粘膜布普伦诺芬稳定.
研究的目的:
- 描述一个使用透皮布伦诺芬加速BUP-XR诱导的案例.
- 评估缩短诱导时间线的可行性和患者体验.
- 评估通过皮肤注射布普伦诺芬在BUP-XR启动期间预防戒断的疗效.
主要方法:
- 包括一个住院患者,有过未经监管的芬太尼使用史.
- 通过皮肤给予布普伦诺芬,持续48小时,以使患者稳定.
- 在加速诱导期后启动了布普伦诺啡延长释放 (BUP-XR).
主要成果:
- 通过皮肤诱导布普伦诺芬促进了BUP-XR的成功启动.
- 患者在诱导过程中经历了最小的戒断症状.
- 在加速方法中没有观察到急性阿片类药物戒断.
结论:
- 加快48小时的透皮布伦诺芬诱导是启动BUP-XR的可行策略.
- 这种以患者为中心的方法可能会减少OUD患者BUP-XR治疗的障碍.
- 需要进一步验证才能将这种方法作为OUD管理的标准临床实践.
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