解开隐藏的深度:基于质谱和分子成像技术的成像多模式集成
Behnaz Akbari1, Bertrand Russell Huber2,3,4,5,6, Janet Hope Sherman2
1Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Critical reviews in analytical chemistry
|October 17, 2023
概括
多模式成像 (MMI) 集成了各种技术进行全面的组织分析,帮助疾病诊断和分子发现. 需要进一步的研究来克服整合挑战,并充分实现MMI.
科学领域:
- 综合生物医学成像和分子病理学.
背景情况:
- 多模式成像 (MMI) 结合了各种成像模式,用于详细的组织分析,包括识别,定位和代谢活动评估.
- MMI有助于疾病进展分析和分子发现,在临床研究和外科手术中越来越多的应用.
- 当前的挑战包括非标准化的特性,定制软件,有限的商业支持和集成复杂性.
研究的目的:
- 审查多式成像 (MMI) 和多组学方法在组织映射和分子病理学的潜力.
- 突出在将基于质谱技术的技术与医学成像模式的整合方面的进展.
- 确定知识差距,并为MMI用于诊断的未来研究提供路线图.
主要方法:
- 审查医学成像模式的最新发展,如MRI和PET.
- 质谱技术的整合,包括成像质谱 (IMS),成像质细胞计 (IMC) 和离子移动性质谱 (IM-IM).
- 应用MMI的多omics方法,使用脱电喷射电离 (DESI) 和矩阵辅助激光脱电离 (MALDI) 进行连续分析.
主要成果:
- 通过MMI,可以同时从多种成像策略获取信号,在无框架立体外科手术中进行手术内应用.
- 在MRI和PET的进步为早期癌症检测,分子跟踪和实时监测提供了新的视角.
- 质谱与医学成像的整合为分子发现和临床应用提供了有前途的途径.
结论:
- 在分子病理学方面,MMI具有显著的潜力,提高了诊断能力.
- 需要进一步的全面研究来验证和整合多种成像技术.
- 未来的研究应该专注于多主题方法,以充分利用MMI在疾病诊断和理解中的价值.
关键词:
绘制图像的质谱仪.磁共振光谱学 磁共振光谱学通过矩阵辅助的激光脱吸.矩阵辅助的激光脱吸电喷离子化电离子化.代谢成像 - - 代谢成像多模式成像技术多模式成像技术定子发射断层扫描 (PET).虚拟多式联络是多元化的.更多相关视频
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