在青春期期间,压力敏感性神经机制的性差异化
Emily C Wright1,2, Pei X Luo1, Hannah C Zakharenkov1
1Department of Psychology, University of California, Davis, CA 95616.
概括
青春期的雄激素会对成年人的压力反应产生影响. 男性和女性早期的雄激素受体激活减少了社会失败效应,影响了与焦虑相关的行为和大脑活动.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为生物学 行为生物学
背景情况:
- 焦虑症不成比例地影响女性,在青春期出现差异.
- 青春期的性腺激素会影响大脑发育和应激敏感性,但机制尚不清楚.
研究的目的:
- 调查青春期的雄激素如何塑造对社会压力的行为和神经反应.
- 确定雄激素受体在编程成人压力敏感性的作用.
主要方法:
- 利用加利福尼亚老鼠 (Peromyscus californicus) 作为研究压力中的性别差异的模型.
- 检查了不同荷尔蒙状态的青少年和成年人 (割,淋巴切除术,雄激素治疗) 对社会失败的行为和神经反应.
- 运用成像在末端的中中床核 (BNST) 评估神经活动.
主要成果:
- 社会压力反应的性别差异在青春期后出现.
- 青春期前割使成年男性对社会失败变得敏感,而成年性腺切除术不会改变反应.
- 在青春期服用二丸激素治疗可以减少社会失败对男性和女性社会态度和警的影响.
- 青春期前割将BNST神经反应推广到不那么危险的社会环境中.
结论:
- 阴道激素,特别是青春期通过雄激素受体作用的雄激素,对于编程成人对社会压力的行为和神经反应至关重要.
- 这些发现突出了BNST在威胁检测中的作用以及雄激素对应激系统的组织效应.
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