建立和验证症状患者的结肠直肠查得分,以预测结肠直肠瘤风险
Xu Wang1, Xi Zhang2, Jiani Liu1
1Tianjin Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Diseases, National Key Clinical Specialty, General Hospital, Tianjin Medical University, Tianjin, China.
Journal of digestive diseases
|October 17, 2023
概括
一个新的症状患者结肠直肠查 (SPCS) 评分有效地识别了那些有非特异性胃肠道症状的人群中患结肠直肠瘤 (CRN) 高风险的个体. 该工具有助于优化结肠镜资源分配,通过将患者分为风险组进行分层.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 目前的结直肠瘤 (CRN) 查主要针对无症状个体.
- 关于非特异性胃肠道症状 (NSGS) 的患者中CRN风险的研究有限.
研究的目的:
- 开发和验证一种新的CRN风险评分,专门用于患有NSGS的患者.
- 为了提高诊断效率和CRN检测的灵敏度在有症状的人群中.
主要方法:
- 预计将招募1522名接受初始结肠镜检查的患者.
- 症状患者结肠直肠查 (SPCS) 评分的发展使用1016名症状患者的培训队列 (70%) 和验证队列 (30%).
- 评估SPCS评分的诊断性能和对结肠镜工作量的影响.
主要成果:
- 与现有系统相比,SPCS得分显示出更高的诊断效率和灵敏度.
- 患者被分为低风险 (-2至3分) 和高风险 (4至10分) 的两组.
- 在高危人群中,CRN检测率为41.7% (培训) 和37.0% (验证),SPCS得分识别了79.3%的CRN和87.5%的高级CRN.
- 结肠镜工作量减少了45.9%.
结论:
- 一个有效的CRN风险评分系统,SPCS评分,成功地建立并验证了症状患者.
- 该SPCS得分准确地将个人分为CRN的低风险和高风险类别.
- 这种评分系统有可能在临床实践中优化结肠镜资源分配.
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