TREM-1,TREM-2及其与COVID-19患者疾病严重程度的关联
Ruyue Fan1, Zuowang Cheng2, Zhisheng Huang3,4
1Shandong Center for Disease Control and Prevention, Jinan, China.
Annals of medicine
|October 17, 2023
概括
在COVID-19患者中,Triggering Receptors Expressed on Myeloid cells (TREM)-1和TREM-2的触发受体表达率较高. 在COVID-19患者中,Triggering Receptors Expressed on Myeloid cells (TREM) -1和TREM-2的触发受体表达率较高. 这些生物标志物对诊断疾病严重程度和识别新的治疗点充满希望.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 生物标志物发现发现
背景情况:
- 有限的生物标志物阻碍了COVID-19患者的及时诊断和治疗.
- 识别新的生物标志物对于理解和管理COVID-19相关的炎症状态至关重要.
研究的目的:
- 在COVID-19患者中调查TREM-1和TREM-2的表达.
- 评估TREM-1和TREM-2作为COVID-19严重程度和治疗目标的潜在生物标志物.
主要方法:
- 用ELISA和流细胞测量来测量COVID-19患者的TREM-1和TREM-2表达.
- 进行了相关性分析,以评估TREM表达和疾病严重程度的临床指标之间的关系.
主要成果:
- 与对照组相比,可溶性TREM-1和TREM-2水平在COVID-19患者中显著增加.
- 在COVID-19患者的T细胞上观察到升调的膜结合TREM-1和TREM-2.
- sTREM-2水平与疾病严重程度标志物 (PaO2/FiO2,CRP,PCT,IL-6) 相相关.
- TREM-1和TREM-2显示出疾病严重程度的预测效果,与CRP和IL-6等已知标志物相比,效果相当.
结论:
- 在应对SARS-CoV-2感染时,TREM-1和TREM-2是关键的宿主免疫因素.
- 这些受体代表了COVID-19的潜在诊断生物标志物.
- TREM-1和TREM-2可以作为COVID-19管理的治疗点.
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