辅助卡纳基努马布降低了外周炎症标志物,并改善了精神分裂症和炎症患者的积极症状:一个随机对照试验
Thomas W Weickert1, Isabella Jacomb2, Rhoshel Lenroot1
1Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.
在精神分裂症患者中,卡纳基努马布有效降低了像hsCRP这样的炎症标志物. 在8周内,hsCRP的降低与积极症状严重程度的降低相关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症治疗缺乏抗炎药物的明显益处,可能是由于未经选择的患者群体.
- 在精神分裂症患者中观察到高水平的互白素1-β (IL-1β),这表明有针对性治疗的作用.
- 卡纳基努马布是一种抗IL-1β抗体,可以减少精神分裂症的炎症和症状.
研究的目的:
- 为了研究卡纳基努马布对外周炎症标志物和精神分裂症患者高炎症症状严重性的作用.
- 评估炎症标志物减少和症状改善之间的相关性.
主要方法:
- 一个随机的,安慰剂控制的双盲试验,涉及27名精神分裂症患者,炎症标志物升高.
- 患者接受了一次性皮下注射卡纳基努马布 (150毫克) 或安慰剂.
- 测量包括hsCRP,NLR,IL-1β,IL-6,IL-8水平和8周的症状严重程度.
主要成果:
- 与安慰剂相比,卡纳基努马布在8周内显著降低了高灵敏性C反应蛋白 (hsCRP) 水平.
- hsCRP的减少与积极症状严重程度的降低密切相关.
- 在负面症状,一般心理病理或认知方面没有观察到任何显著的变化.
结论:
- 在有炎症的精神分裂症患者中,卡纳基努马布迅速降低了外周hsCRP.
- 降低的hsCRP水平与8周后改善的积极症状严重程度相关.
- 需要进行更高剂量或更长时间的进一步研究,以证实canakinumab的治疗潜力.
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