乙型肝炎病毒感染对胆囊息肉风险的影响:一项队列研究
Nam Hee Kim1, Hong Joo Kim1, Ji Hun Kang2
1Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
The Korean journal of internal medicine
|October 17, 2023
概括
乙型肝炎病毒 (HBV) 感染,特别是乙型肝炎表面抗原 (HBsAg) 阳性,与更高的胆囊聚体 (GBPs) 风险有关. 肝炎C病毒 (HCV) 与GBP没有显著的关联.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 病毒性肝炎病毒性肝炎
背景情况:
- 乙型肝炎病毒 (HBV) 和乙型肝炎病毒 (HCV) 感染的患病率有所下降.
- 了解目前胆囊聚体 (GBP) 的风险因素至关重要.
研究的目的:
- 调查HBV或HCV感染是否仍然是胆囊息肉 (GBP) 的重要危险因素.
- 评估病毒性肝炎标志物和GBP发育在一个大无症状成年人队列之间的关联.
主要方法:
- 一项涉及392,913名无症状成年人进行腹部超声波 (美国) 的队列研究.
- 确定GBP的流行率 (≥5毫米,≥10毫米,总体) 和病毒标记物 (HBsAg,HBcAb,抗HCV).
- 进行了统计分析,以评估病毒标志物与英风险之间的关联.
主要成果:
- 皮瘤 (≥5毫米) 的患病率为2.9%, (≥10毫米) 是0.1%,整体为12.8%.
- 乙型肝炎表面抗原 (HBsAg) 阳性与显著增加的GBP风险相关 (OR为≥5毫米1.66,≥10毫米2.39,整体1.49).
- 在抗HCV阳性和英风险之间没有发现显著的关联. 仅仅HBcAb阳性并没有显著增加英风险.
结论:
- 乙型肝炎表面抗原 (HBsAg) 的阳性可能是胆囊聚发展的独立风险因素.
- 对于HBsAg阳性个体,在腹部US期间加强对GBPs的监测可能是合理的.
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