药房分发错误率:一个系统的审查和元分析
Irene S Um1, Alexander Clough1, Edwin C K Tan1
1The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Australia.
Research in social & administrative pharmacy : RSAP
|October 17, 2023
概括
全球药房药物发行错误的流行率为1.6%. 这一系统性审查强调了对标准化定义的需求,以减少全球发布错误报告的差异.
科学领域:
- 制药科学 制药科学
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药店的错误配药可能会导致严重的患者伤害,包括不良药物事件,住院和死亡.
- 量化这些错误的全球流行率对于了解它们的影响和制定减缓策略至关重要.
研究的目的:
- 系统地审查现有的文献,并确定在各种药房设置中全球发行错误的普遍性.
- 确定导致报告的发行错误率异质性的因素.
主要方法:
- 对2010年1月至2023年9月期间发表的研究进行了电子数据库 (EMBASE,MEDLINE,CINAHL) 的全面搜索.
- 包含的研究报告了任何药房设置中发放错误的数据;排除的研究没有报告真正的发放错误.
- 随机效应元分析被用于计算聚合流行率,使用I2统计数据评估异质性. 亚组分析探讨了基于研究特征的变化.
主要成果:
- 包含64项流行率估计的62项研究被纳入了元分析.
- 在所有药房设置中,发行错误的整体综合流行率为1.6% (95% CI 1.2%-2.1%).
- 患病率有很大的差异 (0-33.3%),取决于所使用的分母 (例如,分发的物品,剂量,患者),研究设计和错误识别方法.
结论:
- 全球药物发行错误的流行率估计为1.6%.
- 在分配错误率方面存在显著的异质性,受方法学因素的影响,例如使用的分母和研究设计.
- 为提高数据的一致性和促进全球努力减少对患者的伤害,对发行错误的标准化定义和分类至关重要.
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