相关实验视频

Updated: Jul 13, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

向瘤坏死因子阿尔法,以缓解末囊和辐射诱导的肺损伤

Rama Malaviya¹, Jeffrey D Laskin², Rita Businaro³

¹Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy; Rutgers University, Piscataway, NJ, USA.

Disaster medicine and public health preparedness

|October 17, 2023

概括

子气和辐射会通过DNA损伤和炎症引起肺损伤,增加瘤缩因子α (TNFα). 准TNFα可能会减轻这种毒性.

科学领域:

毒理学毒理学毒理学
免疫学免疫学免疫学
肺部医学肺部医学

背景情况:

子水泡和辐射诱导肺损伤.
这种损伤涉及DNA损伤,氧化应激和炎症.
瘤亡因子-α (TNFα) 和它的受体TNFR1在肺部上调.

研究的目的:

审查TNFα在子和辐射造成的肺损伤中的作用.
探索针对TNFα的治疗策略.

主要方法:

对肺损伤中TNFα研究的文献综述.
分析TNFα信号通路及其对病原发生的贡献.
对TNFα向剂的治疗潜力的评估.

主要成果:

失调的TNFα信号传递有助于肺损伤,氧化应激,亡和亡.
TNFα与慢性炎症,呼吸道过敏反应和组织重塑有关.
准TNFα可能会减少急性和慢性肺毒性.

结论:

在子和辐射引起的肺损伤的病原发生中,TNFα起着至关重要的作用.
抑制TNFα的产生或活性是一种有前途的治疗策略.
对TNFα向剂的进一步研究可能会导致肺损伤的有效治疗方法.

关键词:

肺部受伤的原因是肺部损伤.子水泡植物是子水泡植物.辐射辐射辐射辐射的辐射瘤死亡因子是瘤死亡因子.

更多相关视频

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...