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Updated: Jul 13, 2025

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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Published on: October 4, 2024

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在激活循环和c-终端的Palindromic光基因之间的一种异质交换机控制c-Src功能.

Hipólito Nicolás Cuesta-Hernández1, Julia Contreras1, Pablo Soriano-Maldonado1,2

  • 1Kinases, Protein Phosphorylation and Cancer Group, Structural Biology Programme, Spanish National Cancer Research Center (CNIO), C/Melchor Fernández Almagro num. 3, 28029, Madrid, Spain.

Nature communications
|October 17, 2023
PubMed
概括

在c-Src激酶中的自酸化涉及到Tyr 419和Tyr 530位点之间的切换. 这个过程调节了酶功能和基质相互作用,影响了与癌症相关的突变.

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