突破性感染COVID-19和Toxoplasma gondii之间的关联:一个横截面研究
Marwa A Gouda1, Hind S AboShabaan2, Ahmed S Abdelgawad2
1Department of Clinical and Molecular Parasitology, National Liver Institute, Menoufia University, Shibin El Kom, Menoufia, Egypt. marwa_goda@liver.menofia.edu.eg.
Scientific reports
|October 17, 2023
概括
研究了COVID-19疫苗突破性感染与Toxoplasma gondii (T. gondii) 的共感染情况. 隐性毒素菌在轻微的COVID-19病例中很常见,但没有发现与疾病严重程度的明确联系.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 随着时间的推移,COVID-19疫苗的有效性可能会下降.
- 与其他病原体的同时感染可能会导致突破性感染.
- 东菌 (T. gondii) 在COVID-19突破性感染中的作用尚不清楚.
研究的目的:
- 调查T. gondii联合感染和COVID-19突破性感染之间的关联.
- 评估T. gondii共感染对接种疫苗的个体COVID-19疾病严重性的影响.
主要方法:
- 对330名COVID-19突破性感染的接种疫苗的患者进行横截面研究.
- 使用ELISA对抗T. gondiiIgG和IgM抗体进行查.
- 对T. gondii病毒阳性病例进行PCR测试,以检测寄生虫DNA并与COVID-19严重程度相关联.
主要成果:
- 34.5%的患者有阳性T. gondiiIgG抗体;没有IgM阳性.
- 9.6%的IgG阳性病例通过PCR对T. gondiiDNA呈阳性.
- 较高的T. gondii IgG标位与阳性PCR结果相关 (P < 0.001).
- 在T. gondii感染和COVID-19严重程度之间没有发现显著的相关性.
结论:
- 在轻微的COVID-19突破性感染中观察到隐性毒素菌的高患病率.
- 目前的研究结果未能确定潜伏性毒素菌与COVID-19严重程度之间的明确联系.
- 需要进行更大规模的研究才能充分理解这种关联.
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