来自马格伦海山的抗菌性多基基,来自马格伦海山的真菌Talaromyces scorteusAS-242
Ying Wang1,2, Zhen Ying1,2, Xiao-Ming Li1
1CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao, 266071, China.
The Journal of antibiotics
|October 17, 2023
概括
研究人员从Talaromyces scorteus中发现了新的真菌化合物,塔拉罗德里德G和H和博特里奥罗丁K. 这些新型的nonadride和depsidone衍生物对各种病原体具有显著的抗菌活性.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 药用化学 医学化学
背景情况:
- 海洋衍生真菌是新型生物活性化合物的丰富来源.
- 从马盖伦海山分离出来的Talaromyces scorteus AS-242,其化学成分尚未得到广泛研究.
研究的目的:
- 从Talaromyces scorteus AS-242.2中分离和描述新的化学实体.
- 评估分离化合物的抗微生物潜力.
主要方法:
- 使用广泛的NMR光谱学和质谱学阐明结构.
- 通过X射线晶体分析确认结构和绝对配置.
- 使用微稀释试验进行抗菌活性评估,以确定最小抑制度 (MIC).
主要成果:
- 确定了两种新的非阿德里德衍生物,塔拉罗德里德G (1) 和H (2),以及一种新的德西衍生物,博特里奥罗丁K (3).
- 已知的非阿德里德类比物 (4) 也被分离出来.
- 化合物1,2和3显示出强大的抗菌活性,对抗抗甲素耐药的金黄色葡萄球菌 (MRSA),Vibrio parahaemolyticus和致病真菌 (C. gloeosporioides,F. oxysporum,F. proliferatum).
- MIC值在1至64微克/毫升之间.
结论:
- 塔拉罗米切斯·斯科尔特斯 (Talaromyces scorteus) AS-242在结构上产生了新型的非阿德里德和西衍生物.
- 描述的化合物具有显著的抗微生物特性,突出显示了它们作为新治疗剂的潜在来源的潜力.
- 这项研究代表了非化物类型多基化物的第一个晶体结构.
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