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在期婴儿中新生儿红斑狼的高风险组:出生队列研究

Jingran Ma¹, Zhenghong Li², Hongmei Song¹

¹Department of Pediatrics, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, NO.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

European journal of pediatrics

|October 17, 2023

概括

新生儿红斑狼 (NLE) 即使在产前护理下,也仍然会影响婴儿. 高风险婴儿需要在出生后的第一年内密切监测潜在的皮肤,肝脏或血液系统干扰.

科学领域:

儿科儿科儿科
类风湿病学类风湿病学
免疫学免疫学免疫学

背景情况:

新生儿红斑狼 (NLE) 可以影响婴儿的心脏,皮肤,肝脏和血液系统.
尽管有标准化的产前护理,但NLE的表现如皮肤,肝脏和血液方面的参与可以在产后出现,有时在出生后60天.
没有单一的预测因素被确定为NLE在高风险的婴儿与特定的自身抗体的母亲出生的发展.

研究的目的:

分析临床特征和高风险新生儿红斑狼 (NLE) 的风险因素.
为了确定NLE高风险婴儿的临床表现和结果.
评估NLE中系统性参与和自身抗体清除的时间和解决方案.

主要方法:

对105名孕期婴儿的临床数据进行了回顾性分析,这些婴儿的母亲对抗SSA,抗SSB或抗U1RNP抗体呈阳性.
婴儿分为NLE (30名患者) 和非NLE (75名患者) 组.
从出生到24个月龄的临床数据的随访.

主要成果:

在NLE组中,皮肤 (13.3%),肝脏 (76.0%) 和血液 (43.3%) 系统的参与.
肝脏干扰,贫血和血小板减少在分别在60日,41日和22日的中位数出现.
系统性参与在3-12个月内消失,并且在出生后12个月内清除特定的自身抗体.

结论:

尽管在产前护理中,高风险的NLE婴儿仍然容易受到皮肤,肝脏或血液系统的干扰.
没有任何特定的指标可靠地预测这些高风险婴儿的NLE发展.
在出生后第一年内密切跟踪高风险婴儿至关重要.

关键词:

后续行动后续行动新生儿红血性狼.这就是SSA SSA.这是SSB的SSB.

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