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有效的绿色银纳米颗粒-抗生素组合对抗抗生素耐药细菌

Muhammad Adil^1,2, Siyab Alam¹, Urooj Amin¹

¹Department of Biotechnology, University of Malakand, Chakdara, 18800, Dir Lower, Pakistan.

|October 17, 2023

概括

与抗生素合成银纳米粒子 (AgNPs) 增强了它们的抗菌性能. 这些新型抗生素-AgNP结合体对致病细菌的有效性增加,解决了公众健康问题.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
微生物学微生物学

背景情况:

抗生素耐药细菌对公众健康构成重大威胁.
银纳米粒子 (AgNPs) 具有固有的抗菌特性.
需要新的策略来对抗抗药性病原体引起的不断增加的感染.

研究的目的:

在存在特定抗生素 (Ceftazidime,Cefotaxime,Ceftriaxone,Cefepime) 和孟塔长叶取物的情况下合成AgNP.
描述合成的AgNP的结构性,表面性和抗菌性.
评估抗生素-AgNP结合剂对病原性细菌的增强抗菌活性.

主要方法:

合成AgNPs使用Mentha longifolia提取物作为减少剂和稳定剂,有或没有抗生素.
描述技术包括UV-Vis光谱,里埃变换红外光谱 (FTIR),X射线衍射 (XRD) 和传输电子显微镜 (TEM).
评估表面电荷 (Zeta潜力) 和粒子大小分布 (PDI).

主要成果:

在SPR峰值中观察到的抗生素-AgNP与对照AgNP相比的蓝色转移.
FTIR证实了抗生素-AgNP中存在抗生素特异性峰值.
XRD和TEM揭示了抗生素AgNP的结晶性,大小和分布的变化.
抗生素-AgNP结合物对病原性细菌具有显著增强的抗菌活性.

结论:

在AgNP合成过程中存在抗生素会改变它们的结构性质和表面特征.
与没有抗生素合成的AgNP相比,抗生素-AgNP合体显示出更高的抗菌疗效.
这种方法为开发先进的抗微生物药物来对抗抗生素耐药性提供了一个有希望的战略.

关键词:

抗生素耐药细菌是抗生素耐药的细菌.抗生素抗生素是一种抗生素.头类子素是什么?孟塔长叶植物 (mentha longifolia) 是一种长叶植物.银纳米颗粒银纳米粒子

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