定期运动通过调节抗氧化能力和细胞代谢来延缓微血管内皮功能障碍
Giorgia Scarfò1, Simona Daniele2, Elisa Chelucci3
1Division of General Medicine, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Scientific reports
|October 17, 2023
概括
主体运动员的定期体育活动通过增强血液流动和内皮功能来改善心血管健康. 这种运动诱导的益处与关键的分子和表观遗传调节剂,如氧化和SIRT1.1,有关.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 衰老研究研究 衰老研究
背景情况:
- 衰老是心血管疾病 (CVD) 的首要危险因素.
- 众所周知,定期体育活动 (PA) 可以减轻衰老的影响,并预防内皮功能障碍.
- 主体运动员的PA益处背后的机制仍未得到充分探索.
研究的目的:
- 调查定期PA对老年运动员微循环功能的影响.
- 探索相关的分子和表观遗传变化,包括氧化 (NO),氧化应激,PGC-1α,SIRT1和miR29.
- 为了比较这些影响与年龄相匹配的久坐不动的人.
主要方法:
- 评估了主体运动员和对照者的局部血流对缺血和加热的反应.
- 测量了血中NO度,抗氧化能力和关键调节分子 (PGC-1α,SIRT1,miR29).
- 分析了PGC-1α的转录水平和SIRT1和miR29的血水平.
主要成果:
- 定期的PA显著改善了血 ischemia 和加热后的血液流动,表明增强了微循环功能.
- 运动员表现出更高的血NO度和抗氧化能力.
- 在运动员中观察到PGC-1α,SIRT1和miR29水平的增加,与改善的血流和抗氧化剂状况相关.
结论:
- 在老年运动员中,定期的体育活动为心血管系统带来了显著的益处.
- 增强的微循环功能与改善的内皮功能,抗氧化能力和特定的分子/表观遗传通路有关.
- 作为表观遗传调节剂,SIRT1和miR29可能在调节氧化还原平衡和新陈代谢的运动适应中发挥关键作用.
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