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氧化脂在心血管疾病中的作用

Sotirios Tsimikas¹, Joseph L Witztum²

¹Division of Cardiovascular Medicine, University of California San Diego, La Jolla, CA, USA. stsimikas@health.ucsd.edu.

Nature reviews. Cardiology

|October 17, 2023

概括

氧化脂 (OxPLs) 驱动慢性炎症和动脉样硬化. 在血中测量OxPL-apoB可以改善心血管风险预测,并有助于治疗决策,其性能优于传统标记物.

科学领域:

心血管医学心血管医学
生物化学生物化学
免疫学免疫学免疫学

背景情况:

长时间暴露在氧化脂 (OxPLs) 中会引起慢性炎症,这是动脉样硬化的一个关键因素.
在动脉样硬化病变和质蛋白B (apoB) 含脂蛋白中发现了oxPLs.
血OxPL-apoB水平出乎意料地与脂蛋白 (Lp) 水平有很强的相关性,而不是最小氧化的LDL.

研究的目的:

审查OxPLs在动脉样硬化中的作用和Lp (a) 动脉原性.
讨论OxPL-apoB测量对预后和风险重新分类的有用性.
探索OxPL-apoB水平对治疗干预措施的影响.

主要方法:

实验和临床研究分析,将OxPL-apoB,Lp(a) 与心血管疾病联系起来.
评估OxPL-apoB作为诊断和预后生物标志物.
评估不同降脂疗法对OxPL-apoB水平的变化.

主要成果:

在含有apoB的脂蛋白中,Lp (a) 颗粒携带了大多数OxPLs.
血OxPL-apoB水平提供了对动脉样硬化程度的诊断见解,并改善了对心血管事件的预后.
测量OxPL-apoB可以提高心血管风险的重新分类,特别是在中等风险患者中.

结论:

血OxPL-apoB水平预测心血管事件的准确度与Lp (a) 水平相比或超过.
氧PL-apoB反映了Lp(a) 遗传和脂蛋白氧化,导致炎症.
氧PL-apoB水平通过降低Lp (a) 的疗法,阿菲雷斯,尼亚和腹部手术而降低.

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