在血液学疾病中,与Bacillus cereus bacteremia感染相关的死亡率相关的风险因素
Tomohito Shimada1, Kazuhiro Ishikawa2, Fujimi Kawai3
1Department of Infectious Diseases, St. Luke's International Hospital, 9-1, Akashi-cho, Chuo-ku, Tokyo, Japan.
International journal of hematology
|October 17, 2023
概括
细菌菌在血液学疾病中是致命的,特别是中枢神经系统,肠道或呼吸道感染. 早期使用葡萄糖和源控制显著提高了这些患者的生存机会.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 细菌菌的细菌菌在患有血液学疾病的患者中构成重大威胁.
- 在这个脆弱人群中,B. cereus bacteremia的死亡风险因素在很大程度上仍未确定.
研究的目的:
- 在患有血液学疾病的患者中识别与B. cereus细菌病相关的死亡风险因素.
- 评估特定治疗和感染部位对患者结果的影响.
主要方法:
- 追溯性研究包括176名患有B. cereus细菌病和血液学疾病的患者.
- 从圣卢克斯国际医院和电子数据库收集的数据.
- 进行了单变量和多变量逻辑回归分析,以确定风险和保护因素.
主要成果:
- 总体死亡率为53%,其中141名患者患有急性白血病.
- 中性,中枢神经系统 (CNS),胃肠道 (GI) 和呼吸道感染/症状与死亡率增加有关.
- 葡萄糖的使用和源控制被确定为预防感染相关死亡的保护因素.
结论:
- 中枢神经系统,胃肠道和呼吸道感染/症状显著增加了B. cereus bacteremia的死亡风险.
- 早期给予糖和实施源控制对于改善疑似B. cereus感染患者的生存率至关重要.
相关概念视频
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Pulmonary Tuberculosis I
246
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
246
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.2K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.2K
Healthcare Associated Infections II: Preventive Measures
2.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K
Disorders of Leukocytes
965
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
965
Urinary Tract Infection II: Pathophysiology
18
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
18


