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[¹⁸F]氧葡萄糖正子发射断层扫描/计算机断层扫描特征的初级介质胚芽细胞瘤

Koeun Lee^1,2, Yong-Il Kim³, Jungsu S Oh²

¹Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Scientific reports

|October 17, 2023

概括

[18F]FDG PET/CT视觉吸收强度和SUVmax可以区分良性和恶性原发性中枢胚芽细胞瘤 (MGCTs). SUVmax也可能与AFP水平相关,有助于MGCT诊断和表征.

科学领域:

在瘤学瘤学.
核医学就是核医学.
放射学放射学是一门学科.

背景情况:

原发性中枢胚芽细胞瘤 (MGCTs) 很少见,往往预后比淋巴细胞胚芽细胞瘤更差.
准确区分良性和恶性MGCT对于适当的治疗计划至关重要.

研究的目的:

评估[18F]氧葡萄糖正子发射断层扫描/计算机断层扫描 ([18F]FDG PET/CT) 对区分良性和恶性初级中枢胚芽细胞瘤 (MGCT) 的实用性.
评估成像参数与瘤亚型和血清标志物的相关性.

主要方法:

对35名手术前[18F]FDG PET/CT接受MGCT患者的回顾性审查.
视觉评估吸收强度,分布和轮.
对SUVmax,TBR,MTV和TLG进行定量分析.
接收器操作特征 (ROC) 曲线分析以确定定量参数的诊断性能.

主要成果:

视觉吸收强度对于区分良性和恶性MGCTs具有重要意义 (p=0.040).
定量参数SUVmax (p<0.001),TBR (p<0.001),MTV (p=0.033) 和TLG (p<0.001) 在恶性MGCT中显著更高.
在ROC分析中,SUVmax显示了曲线下的最高面积 (AUC=0.947,p<0.001),并且可以区分精髓瘤和非精髓瘤 (p=0.042),并与AFP水平相关 (p=0.012).

结论:

[18F]FDG PET/CT上的视觉吸收强度和SUVmax对于区分良性与恶性MGCT非常有价值.
SUVmax具有很高的诊断准确性,可以作为MGCT的潜在成像生物标志物,可能反映血清AFP水平.

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