用西梅西康和N-乙囊进行预治疗,以改善上部胃肠内镜检查期间的粘膜可见性:一项随机对照试验
Zaheer Nabi1, Mohan Vamsi2, Rajesh Goud2
1Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India. zaheernabi1978@gmail.com.
赛美西康和N-乙半氨酸 (NAC) 前期治疗显著改善了在食道胃二透镜 (EGD) 期间的粘膜可见性. 单独使用西梅西康是早期内镜治疗中联合前期治疗的有效替代品.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术是一种内镜手术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 消化管胃管腺镜 (EGD) 的诊断性能可能会受到粘液和泡的影响.
- 研究前期药物治疗策略,以加强内镜检查期间的粘膜可视化.
研究的目的:
- 评估前期治疗对EGD期间粘膜可见性的影响.
- 为了比较simethicone的疗效与simethicone和N-乙半氨酸 (NAC) 的组合.
主要方法:
- 这是一项双盲随机试验,涉及800名患者.
- 患者被随机分为四组:水,西米西康 (S),NAC或S+NAC.
- 粘膜可见度被分级,并计算了全粘膜可见度得分 (TMVS);主要结果是西米西康和组合组之间的TMVS比较.
主要成果:
- 与水和NAC组相比,Simethicone (S) 和S+NAC组的TMVS显著降低.
- 在71% (S) 和79% (S + NAC) 的患者中,达到了足够的胃粘膜可见性,而在26% (水) 和36% (NAC) 的患者中,达到了足够的可见性.
- 两组之间没有观察到病变检测率的显著差异.
结论:
- 使用西梅西康或S + NAC的前期治疗显著改善了EGD期间的粘膜可见性.
- 单独的Simethicone提供了与早期内镜联合前期治疗相比较的粘膜可见性,作为一种有效的替代方案.
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